Phospho-HDAC7A (Ser155) In-Cell ELISA

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SKU:
CBCAB01700
Product Type:
ELISA Kit
ELISA Type:
Cell Based Phospho Specific
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Detection Method:
Colorimetric

Description

Technical Manual

Phospho-HDAC7A (Ser155) Cell-Based ELISA

Product Description:The Phospho-HDAC7A (Ser155) Colorimetric Cell-Based ELISA Kit allows for qualitative detection of Phospho-HDAC7A(Ser155) in plated and fixed cells.
Target Synonyms:HD7a; HDA7; HDAC7A; Histone deacetylase 7a
Detection Target:Phospho-IRAK1(Thr209)
Reactivity:H:S155, M:S178, R:S164
Pack Size:2 x 96 assays
Detection Method:Colorimetric 450 nm
Format:Cell-Based ELISA/In-Cell ELISA
Storage and Stability Guarantee:4 °C/6 Months
Sample Type:Plated & fixed cells
Range:5000 cells/well minimum
Time:4.5 hours

Phospho-HDAC7A (Ser155) Cell-Based ELISA Protein Information

UniProt Protein Function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
NCBI Summary:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WUI4
NCBI GenInfo Identifier:30913097
NCBI Gene ID:51564
NCBI Accession:Q8WUI4.2
UniProt Secondary Accession:Q8WUI4,Q6P1W9, Q6W9G7, Q7Z4K2, Q7Z5I1, Q96K01, Q9BR73 Q9H7L0, Q9NW41, B3KY08, B4DWI0, B4E0Q5,
UniProt Related Accession:Q8WUI4
Molecular Weight:66,187 Da
NCBI Full Name:Histone deacetylase 7
NCBI Synonym Full Names:histone deacetylase 7
NCBI Official Symbol:HDAC7
NCBI Official Synonym Symbols:HD7; HD7A; HDAC7A
NCBI Protein Information:histone deacetylase 7
UniProt Protein Name:Histone deacetylase 7
UniProt Synonym Protein Names:Histone deacetylase 7A; HD7a
Protein Family:Histone deacetylase
UniProt Gene Name:HDAC7
UniProt Entry Name:HDAC7_HUMAN
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