| UniProt Protein Function: | Ets-1: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described.Protein type: Motility/polarity/chemotaxis; Transcription factor; Oncoprotein; DNA-bindingChromosomal Location of Human Ortholog: 11q23.3Cellular Component: nucleoplasm; transcription factor complex; intercellular bridge; cytoplasm; nucleusMolecular Function: histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor activityBiological Process: transcription from RNA polymerase II promoter; hypothalamus development; positive regulation of erythrocyte differentiation; positive regulation of transcription, DNA-dependent; cell motility involved in cell locomotion; PML body organization and biogenesis; female pregnancy; positive regulation of cell motility; angiogenesis involved in wound healing; regulation of angiogenesis; response to estradiol stimulus; negative regulation of cell cycle; regulation of apoptosis; response to antibiotic; negative regulation of cell proliferation; positive regulation of angiogenesis; pituitary gland development; response to mechanical stimulus; positive regulation of cell proliferation; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; immune response |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P27577 |
| NCBI GenInfo Identifier: | 219689118 |
| NCBI Gene ID: | 2113 |
| NCBI Accession: | NP_001137292.1 |
| UniProt Secondary Accession: | P27577,Q14278, Q16080, Q6N087, Q96AC5, A9UL17, F5GYX9 |
| UniProt Related Accession: | P27577,P14921 |
| Molecular Weight: | |
| NCBI Full Name: | protein C-ets-1 isoform 1 |
| NCBI Synonym Full Names: | v-ets avian erythroblastosis virus E26 oncogene homolog 1 |
| NCBI Official Symbol: | ETS1 |
| NCBI Official Synonym Symbols: | p54; ETS-1; EWSR2 |
| NCBI Protein Information: | protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1 |
| UniProt Protein Name: | Protein C-ets-1 |
| UniProt Synonym Protein Names: | p54 |
| Protein Family: | Protein |
| UniProt Gene Name: | ETS1 |
| UniProt Entry Name: | ETS1_HUMAN |
