The PerCP-Cyanine5.5 Anti-Human CD28 Antibody, also known as CD28-2, offered by AssayGenie, is a vital tool for researchers investigating CD28, a crucial co-stimulatory molecule involved in T cell activation and immune responses. This antibody is specifically designed to target human CD28 with high precision and sensitivity, making it an excellent choice for a variety of immunology studies.CD28 is an essential receptor on T cells that provides a co-stimulatory signal required for T cell activation, proliferation, and cytokine production. It plays a pivotal role in shaping the adaptive immune response by promoting T cell differentiation and effector functions. By accurately detecting and analyzing CD28 expression in various cell types, this antibody facilitates detailed exploration of immune responses and regulatory pathways.
The PerCP-Cyanine5.5 Anti-Human CD28 Antibody from AssayGenie is meticulously validated for use in flow cytometry applications, enabling researchers to profile and quantify CD28 expression on the surface of human cells with high specificity and accuracy. Whether investigating immune regulation, T cell signaling, or therapeutic interventions targeting CD28, this antibody provides valuable support for in-depth studies in immunology and related fields.Unlock the potential of your research with the PerCP-Cyanine5.5 Anti-Human CD28 Antibody from AssayGenie, a reliable tool for investigating the role of CD28 in immune responses and advancing our understanding of T cell biology.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P10747
Gene ID:
940
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
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