Description

PE/Cyanine7 Anti-Mouse CD54 Antibody [YN1/1.7.4]

The PE-Cyanine7 Anti-Mouse CD54 Antibody (YN1/1.7.4) from AssayGenie is a high-quality research tool designed for the detection and analysis of CD54, a cell adhesion molecule involved in immune responses. This specific antibody, suitable for use with mouse samples, has been rigorously validated for use in flow cytometry and immunofluorescence applications. CD54, also known as intercellular adhesion molecule-1 (ICAM-1), plays a vital role in the immune system by mediating cell-to-cell interactions and facilitating processes such as leukocyte recruitment and inflammation. Its expression levels and activity can have significant implications in various immune-related disorders, including inflammatory diseases, infections, and autoimmune conditions.

With its exceptional specificity and sensitivity, the PE-Cyanine7 Anti-Mouse CD54 Antibody offers researchers a powerful tool for investigating the functions and regulatory mechanisms of CD54 in immunology and related fields. Its ability to precisely target CD54 protein in mouse samples makes it an invaluable asset for studies aimed at elucidating the role of this molecule in health and disease.

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Product Title:	PE/Cyanine7 Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:	AGEL2155
Size:	50 Tests, 100 Tests, 200 Tests
Clone No:	YN1/1.7.4
Synonyms:	Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG2b, κ
Isotype Control:	PE/Cyanine7 Rat IgG2b, κ Isotype Control[LTF-2]
Form:	Liquid
Conjugation:	PE/Cyanine 7
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P13597
Gene ID:	15894
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

PE/Cyanine7 Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL2155)

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