PCSK9 Polyclonal Antibody (CAB24478)
- SKU:
- CAB24478
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | PCSK9 Polyclonal Antibody |
| Product Code: | CAB24478 |
| Reactivity: | Human, Rat |
| Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Rat |
| Tested Applications: | WB, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:100-1:500, IF/ICC 1:50-1:200, IP 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Hep G2, HeLa |
| Cellular Location: | Cell surface, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Secreted |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-692 of human PCSK9 (NP_777596.2). |
| Sequence: | QEDED GDYEE LVLAL RSEED GLAEA PEHGT TATFH RCAKD PWRLP GTYVV VLKEE THLSQ SERTA RRLQA QAARR GYLTK ILHVF HGLLP GFLVK MSGDL LELAL KLPHV DYIEE DSSVF AQSIP WNLER ITPPR YRADE YQPPD GGSLV EVYLL DTSIQ SDHRE IEGRV MVTDF ENVPE EDGTR FHRQA SKCDS HGTHL AGVVS GRDAG VAKGA SMRSL RVLNC QGKGT VSGTL IGLEF IRKSQ LVQPV GPLVV LLPLA GGYSR VLNAA CQRLA RAGVV LVTAA GNFRD DACLY SPASA PEVIT VGATN AQDQP VTLGT LGTNF GRCVD LFAPG EDIIG ASSDC STCFV SQSGT SQAAA HVAGI AAMML SAEPE LTLAE LRQRL IHFSA KDVIN EAWFP EDQRV LTPNL VAALP PSTHG AGWQL FCRTV WSAHS GPTRM ATAVA RCAPD EELLS CSSFS RSGKR RGERM EAQGG KLVCR AHNAF GGEGV YAIAR CCLLP QANCS VHTAP PAEAS MGTRV HCHQQ GHVLT GCSSH WEVED LGTHK PPVLR PRGQP NQCVG HREAS IHASC CHAPG LECKV KEHGI PAPQE QVTVA CEEGW TLTGC SALPG TSHVL GAYAV DNTCV VRSRD VSTTG STSEG AVTAV AICCR SRHLA QASQE LQ |
| Synonyms: | PCSK9, FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, proprotein convertase subtilisin/kexin type 9 |
| Calculated MW: | 20kDa/74kDa |
| Observed MW: | 65kDa/80kDa |
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