PARP1 Polyclonal Antibody (CAB22534)

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SKU:
CAB22534
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:PARP1 Polyclonal Antibody
Product Code:CAB22534
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Jurkat
Cellular Location:cytosol, mitochondrion, nuclear body, nuclear envelope, nuclear replication fork, nucleolus, nucleoplasm, nucleus

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human PARP1. (NP_001609.2).
Sequence:PGVKS EGKRK GDEVD GVDEV AKKKS KKEKD KDSKL EKALK AQNDL IWNIK DELKK VCSTN DLKEL LIFNK QQVPS GESAI LDRVA DGMVF GALLP CEECS G
Synonyms:PARP, PARS, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1, Poly-PARP
Calculated MW:113kDa
Observed MW:89kDa
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