Notch1 Polyclonal Antibody (CAB21516)
- SKU:
- CAB21516
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | Notch1 Polyclonal Antibody |
| Product Code: | CAB21516 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IF/ICC, ELISA |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Nucleus, Single-pass type I membrane protein |
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2456-2555 of human Notch1 (NP_060087.3). |
| Sequence: | ILPQE SPALP TSLPS SLVPP VTAAQ FLTPP SQHSY SSPVD NTPSH QLQVP EHPFL TPSPE SPDQW SSSSP HSNVS DWSEG VSSPP TSMQS QIARI PEAFK |
| Synonyms: | hN1, AOS5, TAN1, AOVD1 |
| Calculated MW: | 273kDa |
| Observed MW: | Refer to figures |
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