NF-κB2 Polyclonal Antibody
- SKU:
- CAB21509
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | NF-κB2 Polyclonal Antibody |
| Product Code: | CAB21509 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Nucleus |
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human NF-κB2 (NP_001070962.1). |
| Sequence: | GGGGG AQMAA TVPSR DSGEE AAEPS APSRT PQCEP QAPEM LQRAR EYNAR LFGLA QRSAR ALLDY GVTAD ARALL AGQRH LLTAQ DENGD TPLHL AIIHG Q |
| Synonyms: | p52, p100, H2TF1, LYT10, CVID10, LYT-10, NF-kB2, p49/p100 |
| Calculated MW: | 97kDa |
| Observed MW: | Refer to figures |
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