NBS1/NBN Polyclonal Antibody
- SKU:
- CAB21501
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | NBS1/NBN Polyclonal Antibody |
| Product Code: | CAB21501 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:2000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Chromosome, Nucleus, PML body, telomere |
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 650-750 of human NBS1/NBN (NP_002476.2). |
| Sequence: | LPKKL LLTEF RSLVI KNSTS RNPSG INDDY GQLKN FKKFK KVTYP GAGKL PHIIG GSDLI AHHAR KNTEL EEWLR QEMEV QNQHA KEESL ADDLF RYNPY L |
| Synonyms: | ATV, NBS, P95, NBS1, AT-V1, AT-V2 |
| Calculated MW: | 85kDa |
| Observed MW: | Refer to figures |
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