NBS1/NBN Polyclonal Antibody

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SKU:
CAB21501
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF

Description

Product Name:NBS1/NBN Polyclonal Antibody
Product Code:CAB21501
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500-1:2000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location:Chromosome, Nucleus, PML body, telomere

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 650-750 of human NBS1/NBN (NP_002476.2).
Sequence:LPKKL LLTEF RSLVI KNSTS RNPSG INDDY GQLKN FKKFK KVTYP GAGKL PHIIG GSDLI AHHAR KNTEL EEWLR QEMEV QNQHA KEESL ADDLF RYNPY L
Synonyms:ATV, NBS, P95, NBS1, AT-V1, AT-V2
Calculated MW:85kDa
Observed MW:Refer to figures
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