Myelin Protein Zero (MPZ) Monoclonal Antibody
- SKU:
- CAB21931
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Myelin Protein Zero (MPZ) Monoclonal Antibody |
| Product Code: | CAB21931 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53696 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:10000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse Spinal cord, Mouse Skeletal muscle, Rat Skeletal muscle |
| Cellular Location: | Cell membrane, Myelin membrane, Single-pass type I membrane protein |
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 149-248 of human Myelin Protein Zero (MPZ) (NP_000521.2). |
| Sequence: | KVPTR YGVVL GAVIG GVLGV VLLLL LLFYV VRYCW LRRQA ALQRR LSAME KGKLH KPGKD ASKRG RQTPV LYAML DHSRS TKAVS EKKAK GLGES RKDKK |
| Synonyms: | P0, CHM, DSS, MPP, CHN2, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, HMSNIB |
| Calculated MW: | 28kDa |
| Observed MW: | 28kDa |
Related Products
Human MPZL1（Myelin protein zero like 1） ELISA Kit
