MYD88 Monoclonal Antibody [PAT22F11A] (CPAB0575)
![MYD88 Monoclonal Antibody [PAT22F11A] (CPAB0575)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58796/63978/myd88-monoclonal-antibody-pat22f11a-cpab0575__95238__36855.1706535220.jpg?c=1 "MYD88 Monoclonal Antibody [PAT22F11A] (CPAB0575)")
- SKU:
- CPAB0575
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Clone:
- PAT22F11A
- Applications:
- WB
- Applications:
- ELISA
![MYD88 Monoclonal Antibody [PAT22F11A] (CPAB0575)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58796/63978/myd88-monoclonal-antibody-pat22f11a-cpab0575__95238__36855.1706535220.jpg?c=1&imbypass=on "MYD88 Monoclonal Antibody [PAT22F11A] (CPAB0575)")
Description
system_update_alt Datasheet
| Product Name: | MYD88 Antibody |
| Product Sku: | CPAB0575 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human MYD88 mAb, clone PAT22F11A, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MYD88 protein 1-39 amino acids purified from Ecoli. |
| Clone: | PAT22F11A. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA |
| Purification Method: | MYD88 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2b |
| Background: | Myeloid differentiation primary response gene 88 (MYD88) is a cytosolic adapter protein, which has a central role in the innate and adaptive immune response. MYD88 functions as a vital signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. MYD88 acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The MYD88 protein increases IL-8 transcription. MYD88 is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1, resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MYD88 is comprised of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in the MYD88 gene have an increased susceptibility to pyogenic bacterial infections. |
| Synonyms: | Myeloid differentiation primary response protein MyD88, MYD88, MYD88D. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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