Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.
Product Name:
Mouse SRC Kinase/c-SRC Recombinant Protein (RPES1995)
Product Code:
RPES1995
Size:
20µg
Species:
Mouse
Expressed Host:
Baculovirus-Insect Cells
Synonyms:
AW259666,pp60c-src
Accession:
NP_001020566.111
Sequence:
Met 1-Leu 535
Fusion tag:
N-His-GST
Activity:
1. The specific activity was determined to be ?80 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.2. Measured by its binding ability in a functional ELISA. Immobilized recombinant Mouse SRC at 2 µg/ml (100 ?l/well) can bind biotinylated human PTPRA (aa 174-793) with a linear range of 0.032-0.8 µg/ml.
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the mouse SRC (NP_001020566.111) (Met 1-Leu 535) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
system_update_altDatasheetHuman SRC Kinase/c-SRC Recombinant Protein Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members
system_update_altDatasheetMouse CSK/C-Src kinase Recombinant Protein The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration. These functions
system_update_altDatasheetMouse CSK/C-Src kinase Recombinant Protein The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration. These functions
system_update_altDatasheetHuman CSK/C-Src kinase Recombinant Protein The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration. These functions
