Mouse SMAD2 Recombinant Protein (RPES5003)
- SKU:
- RPES5003
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse SMAD2 Recombinant Protein
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. Phosphorylated SMAD2 is able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression.
| Product Name: | Mouse SMAD2 Recombinant Protein (RPES5003) |
| Product Code: | RPES5003 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | 7120426M23Rik,Madh2,Madr2,mMad2,Smad-2 |
| Accession: | Q62432-Isoform Long |
| Sequence: | Ser2-Ser467 |
| Fusion tag: | N-His-GST |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse SMAD2 (Q62432-Isoform Long) (Ser2-Ser467) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 90 % as determined by SDS-PAGE |
| Mol Mass: | 80 kDa |
| AP Mol Mass: | 90 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris, 500mM Nacl, pH 8.0, 10% glycerol, 3mM DTT |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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