Mouse SLAMF5/CD84 Recombinant Protein (RPES4711)
- SKU:
- RPES4711
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse SLAMF5/CD84 Recombinant Protein
The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.
| Product Name: | Mouse SLAMF5/CD84 Recombinant Protein (RPES4711) |
| Product Code: | RPES4711 |
| Size: | 50µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | SLAM family member 5, Cd84, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5, CD84, Ly-9B, SLAMF5, CD84 antigen, CD84 molecule, SLAM family member 5 |
| Accession: | Q18PI6-1 |
| Sequence: | Met 1-Val 221 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse CD84 isoform 1 (Q18PI6-1) extracellular domain (Met 1-Val 221) was expressed, with a polyhistidine tag at the C-terminus. |
| Purity: | > 97 % as determined by SDS-PAGE |
| Mol Mass: | 24 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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