SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement system to prevent spontaneous activation. SERPIN G1 may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. SERPIN G1 prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. SERPIN G1 is a very efficient physiological inhibitor of FXIIa, plasma kallikrein and fXIa, and could inhibit chymotrypsin and kallikrein. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases in the C1 complex of classical pathway of complement. Activation of the C1 complex is under control of the C1-inhibitor.
Product Name:
Mouse Serpin G1/C1IN Recombinant Protein (RPES2934)
Recombinant Mouse Serine Protease Inhibitor-clade G1 is produced by our Mammalian expression system and the target gene encoding Ala20-Gly504 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
54.6 kDa
AP Mol Mass:
90 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM TrisHCl, 150mM NaCl,pH8.0.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetMouse Serpin A3N Recombinant Protein Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to ?1 antichymotrypsin encoded
system_update_altDatasheetMouse Serpin E1/PAI Recombinant Protein Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts a
system_update_altDatasheetMouse Serpin F1/PEDF Recombinant Protein Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has bot
system_update_altDatasheetMouse Serpin F1/PEDF Recombinant Protein Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric gl
system_update_altDatasheetHuman SerpinG1/C1IN Recombinant Protein Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine p
