Mouse Pleiotrophin Recombinant Protein (RPES3278)

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SKU:
RPES3278
Product Type:
Recombinant Protein
Species:
Mouse

Description

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Mouse Pleiotrophin Recombinant Protein

HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.

Product Name:Mouse Pleiotrophin Recombinant Protein (RPES3278)
Product Code:RPES3278
Size:50µg
Species:Mouse
Expressed Host:HEK293 Cells
Synonyms:Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Osteoblast-specific factor 1, OSF-1,HARP,HB-GAM,HBBN,HBNF,OSF,Osf-1,Osf1
Accession:P63089
Sequence:Gly 33-Asp 168
Fusion tag:N-Fc
Endotoxin:<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:A DNA sequence encoding the mouse PTN (P63089) (Gly 33-Asp 168) was fused with the Fc region of human IgG1 at the N-terminus.
Purity:> 85 % as determined by SDS-PAGE
Mol Mass:43.7 kDa
AP Mol Mass:47 kDa
Formulation:Lyophilized from sterile PBS, pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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