Cell Biology Recombinant Proteins
Mouse P-selectin/CD62P Recombinant Protein (RPES2408)
- SKU:
- RPES2408
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Research Area:
- Cell Biology
Description
Mouse P-selectin/CD62P Recombinant Protein
P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. it also mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P-selectin interacts with SNX17, PSGL1/SEPL, PODXL2, mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
| Product Name: | Mouse P-selectin/CD62P Recombinant Protein (RPES2408) |
| Product Code: | RPES2408 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | P-selectin, CD62 antigen-like family member P, Granule membrane protein 140, GMP-140, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, PADGEM |
| Accession: | Q01102 |
| Sequence: | Trp42-Ala709 |
| Fusion tag: | C-AVI-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Biotinylated Recombinant Mouse P-selectin is produced by our Mammalian expression system and thetarget gene encoding Trp42-Ala709 is expressed with a Avi, 6His tag at the C-terminus. |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
| Mol Mass: | 75.2 kDa |
| AP Mol Mass: | 110-130 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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