Mouse NCR1 Recombinant Protein (RPES2357)
- SKU:
- RPES2357
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse NCR1 Recombinant Protein
Natural cytotoxicity triggering receptor 1(NKp46/NCR1) is a single-pass type I membrane protein. It consists of two extracellular Ig-like domains followed by a short stalk region, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmictail. NKp46 is predominantly expressed in the embryo. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor celllines.
| Product Name: | Mouse NCR1 Recombinant Protein (RPES2357) |
| Product Code: | RPES2357 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | Activating receptor1, mAR-1, Lymphocyte antigen94, Naturalkiller cell p46-related protein, NK-p46, NKp46, mNKp46 |
| Accession: | Q8C567 |
| Sequence: | Glu22-Asn255 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse Natural cytotoxicity triggering receptor 1 is produced by our Mammalian expression system and the target gene encoding Glu22-Asn255 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 53.5 kDa |
| AP Mol Mass: | 76kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4 . |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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