As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (Fc?R ) on phagocytic cells with high affinity.
Product Name:
Mouse IgG1 Fc/IGHG1 Recombinant Protein (RPES1098)
Product Code:
RPES1098
Size:
10µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
g gamma-1 chain C region,IGHG1
Accession:
P01868
Sequence:
Pro99-Lys324
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Mouse Immunoglobulin G1 Fc is produced by our Mammalian expression system and the target gene encoding Pro99-Lys324 is expressed.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
41.5 kDa
AP Mol Mass:
30kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetMouse IgG1-Fc Recombinant Protein (102 Cys/Ser) As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that
Human IgG1 Fc Recombinant Protein (RPES5961)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!
Human IgG1-Fc Recombinant ProteinDescription:IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)) is a Protein Coding gene. Diseases associated with IGHG1 include Leukemia, Chronic...
system_update_altDatasheetMouse IgG3-Fc Recombinant Protein As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass thro
