Mouse CD80 Monoclonal Antibody [16-10A1](AGEL0034)

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SKU:
AGEL0034
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Hamster
Isotype:
IgG
Clone:
16-10A1
Conjugation:
Unconjugated
Applications:
FC
Applications:
IHC
Applications:
IP

Description

system_update_altDatasheet
Antibody Name:Mouse CD80 Monoclonal Antibody
Antibody Code:AGEL0034
Size:100µg
Clone:16-10A1
Synonyms:T-lymphocyte activation antigen CD80, Cd80, Activation B7-1 antigen, B7
Host Species:Hamster
Species Reactivity:Mouse
Applications:FC, IHC, IP
Concentration:1mg/mL
Isotype:IgG
Conjugation:Unconjugated
Applications:FC, IHC, IP
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300
Storage:Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Gene ID:12519
Uniprot:Q00609
Background:CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.
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