Mouse CD54 Monoclonal Antibody [YN1/1.7.4](AGEL0116)

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SKU:
AGEL0116
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
YN1/1.7.4
Conjugation:
Unconjugated
Applications:
FC
Applications:
WB
Applications:
IHC
Applications:
IP

Description

system_update_altDatasheet
Antibody Name:Mouse CD54 Monoclonal Antibody
Antibody Code:AGEL0116
Size:100µg
Clone:YN1/1.7.4
Synonyms:Intercellular adhesion molecule 1, Icam1, MALA-2, MyD10, CD54, Icam-1
Host Species:Rat
Species Reactivity:Mouse
Applications:FC, WB, IHC, IP
Concentration:1mg/mL
Isotype:IgG2b
Conjugation:Unconjugated
Applications:FC, WB, IHC, IP
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300
Storage:Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Gene ID:15894
Uniprot:P13597
Background:CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
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