Name: Mouse CD103 Monoclonal Antibody (Biotin Conjugated) [M290](AGEL0331)
SKU: AGEL0331
Availability: OutOfStock

Mouse CD103 Monoclonal Antibody (Biotin Conjugated) [M290](AGEL0331)

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SKU:

AGEL0331

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Mouse

Host Species:

Rat

Isotype:

IgG2a

Clone:

M290

Conjugation:

Biotin

Applications:

Description

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OverviewAntibody Name:Mouse CD103 Monoclonal Antibody (AF488 Conjugated)Antibody Code:AGEL1161Size:50µgClone:M290

system_update_altDatasheetOverviewAnti

OverviewAntibody Name:Mouse CD103 Monoclonal Antibody (APC Conjugated)Antibody Code:AGEL1146Size:50 TestsClone:M290Syn

OverviewAntibody Name:Mouse CD103 Monoclonal Antibody (PE Conjugated)Antibody Code:AGEL1154Size:50µgClone:M290Sy

OverviewAntibody Name:Mouse CD103 Monoclonal Antibody (AF647 Conjugated)Antibody Code:AGEL1152Size:50 TestsClone:M290S

Concentration:	1mg/mL
Isotype:	IgG2a
Conjugation:	Biotin
Applications:	FC
Recommended Dilution:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:	PBS with 0.05% Proclin300, 1% BSA
Storage:	Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.

Gene ID:	16407
Uniprot:	Q60677
Background:	CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.