Mouse Bax Recombinant Protein (RPPB2855)
- SKU:
- RPPB2855
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q07813
Description
| Product Name: | Mouse Bax Recombinant Protein |
| Product Code: | RPPB2855 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | Bax |
| Synonyms: | Apoptosis regulator BAX membrane isoform alpha, Bax, Bcl2-associated X protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The 1mg/ml protein contains 10mM Tris-HCl pH-8, 1mM EDTA and 150mM NaCl, 10% glycerol, 0.1% tween & 10mM glutathione. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
Bcl-2�associated X protein (Bax) belongs to the Bcl-2 protein family.Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains.Bax accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor bcl2 or its adenovirus homolog e1b 19k protein. Bax induces the release of cytochrome c, activation of casp3, and thereby apoptosis. Bax is expressed in a wide variety of tissues, with highest levels in the testis and ovary.Tumor suppressor protein p53 upregulates the expression of BAX. Bax has been shown to be involved in p53-mediated apoptosis.
Bax Mouse Recombinant amino acid 1-171 produced in E.Coli is a single, non-glycosylated polypeptide chain. The Mouse Bax is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BAX: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37. Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. Belongs to the Bcl-2 family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Apoptosis; Membrane protein, integral; Mitochondrial Cellular Component: mitochondrial permeability transition pore complex; endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; cell; integral to membrane; nuclear envelope; cytosol; pore complex; mitochondrial outer membrane; membrane; cytoplasm; mitochondrial membrane; intracellular; nucleus Molecular Function:BH domain binding; identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; channel activity; heat shock protein binding; chaperone binding; BH3 domain binding; protein complex binding; lipid binding Biological Process: hypothalamus development; regulation of cell cycle; positive regulation of apoptosis; response to toxin; germ cell programmed cell death; myeloid cell homeostasis; homeostasis of number of cells; B cell apoptosis; post-embryonic development; germ cell development; regulation of mammary gland epithelial cell proliferation; regulation of apoptosis; spermatid differentiation; development of secondary sexual characteristics; regulation of mitochondrial membrane potential; protein insertion into mitochondrial membrane during induction of apoptosis; regulation of neuron apoptosis; establishment and/or maintenance of transmembrane electrochemical gradient; negative regulation of neuron apoptosis; negative regulation of protein binding; kidney development; inner mitochondrial membrane organization and biogenesis; nervous system development; release of cytochrome c from mitochondria; outer mitochondrial membrane organization and biogenesis; positive regulation of B cell apoptosis; regulation of protein homodimerization activity; cellular respiration; vagina development; protein oligomerization; fertilization; induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of fibroblast proliferation; retina development in camera-type eye; reduction of endoplasmic reticulum calcium ion concentration; glycosphingolipid metabolic process; cerebral cortex development; response to ionizing radiation; mitochondrial fragmentation during apoptosis; regulation of nitrogen utilization; post-embryonic camera-type eye morphogenesis; positive regulation of pigmentation; regulation of protein heterodimerization activity; T cell homeostatic proliferation; apoptosis; negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis involved in mammary gland involution; neuron migration; regulation of caspase activity; release of matrix enzymes from mitochondria; response to salt stress; negative regulation of cell proliferation; positive regulation of protein oligomerization; apoptotic mitochondrial changes; B cell homeostatic proliferation; B cell homeostasis; ovarian follicle development; positive regulation of neuron apoptosis; response to wounding; response to gamma radiation; B cell negative selection; response to axon injury; transmembrane transport; protein homooligomerization; leukocyte homeostasis; caspase activation; mitochondrial fusion; transformed cell apoptosis; male gonad development; Sertoli cell proliferation; limb morphogenesis; odontogenesis of dentine-containing teeth; cell proliferation; neuron apoptosis; homeostasis of number of cells within a tissue; spermatogenesis; retinal cell programmed cell death; blood vessel remodeling; caspase activation via cytochrome c; positive regulation of release of sequestered calcium ion into cytosol; response to DNA damage stimulus; sex differentiation |
| UniProt Code: | Q07813 |
| NCBI GenInfo Identifier: | 6680770 |
| NCBI Gene ID: | 12028 |
| NCBI Accession: | NP_031553.1 |
| UniProt Related Accession: | Q07813 |
| Molecular Weight: | |
| NCBI Full Name: | apoptosis regulator BAX |
| NCBI Synonym Full Names: | BCL2-associated X protein |
| NCBI Official Symbol: | Bax�� |
| NCBI Protein Information: | apoptosis regulator BAX |
| UniProt Protein Name: | Apoptosis regulator BAX |
| Protein Family: | Protein |
| UniProt Gene Name: | Bax�� |
| UniProt Entry Name: | BAX_MOUSE |
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