Mouse BACE2/Beta secretase 2 Recombinant Protein (RPES3080)
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Description
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Mouse BACE2/Beta secretase 2 Recombinant Protein
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
| Product Name: | Mouse BACE2/Beta secretase 2 Recombinant Protein (RPES3080) |
| Product Code: | RPES3080 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | 1110059C24Rik,AEPLC,AI850424,ALP56,ARP1,ASP21,BAE2,CDA13,CEAP1,DRAP |
| Accession: | Q9JL18 |
| Sequence: | Met1-Pro462 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 .The specific activity is >50 pmoles/min/µg. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 49.2 kDa |
| AP Mol Mass: | 55 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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