Description
Antibody Name: | MKNK2 Antibody |
Antibody SKU: | PACO02788 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Mnk2. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MKNK2; GPRK7; MNK2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2 |
UniProt Protein Function: | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q9HBH9 |
NCBI GenInfo Identifier: | 90102033 |
NCBI Gene ID: | 2872 |
NCBI Accession: | Q9HBH9.3 |
UniProt Secondary Accession: | Q9HBH9,Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6 |
UniProt Related Accession: | Q9HBH9 |
Molecular Weight: | Da |
NCBI Full Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
NCBI Synonym Full Names: | MAP kinase interacting serine/threonine kinase 2 |
NCBI Official Symbol: | MKNK2 |
NCBI Official Synonym Symbols: | MNK2; GPRK7 |
NCBI Protein Information: | MAP kinase-interacting serine/threonine-protein kinase 2 |
UniProt Protein Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
UniProt Synonym Protein Names: | MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2 |
Protein Family: | MAP kinase-interacting serine/threonine-protein kinase |
UniProt Gene Name: | MKNK2 |
UniProt Entry Name: | MKNK2_HUMAN |