MGMT Monoclonal Antibody
- SKU:
- CAB23520
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | MGMT Monoclonal Antibody |
| Product Code: | CAB23520 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55549 |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:10000-1:40000, IHC-P 1:50-1:200, IF/ICC 1:100, -1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, MCF7 |
| Cellular Location: | Nucleus |
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.
| Immunogen: | Recombinant protein of human MGMT. |
| Sequence: | Email for sequence |
| Synonyms: | MGMT, O-6-methylguanine-DNA methyltransferase |
| Calculated MW: | 22kDa |
| Observed MW: | 22kDa |
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