Mesothelin Monoclonal Antibody (CAB21982)

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SKU:
CAB21982
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC

Description

Product Name:Mesothelin Monoclonal Antibody
Product Code:CAB21982
Reactivity:Human
Applications:Western blotting, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC54390
Reactivity:Human
Tested Applications:WB, IHC-P, ELISA
Key Applications:Western blotting, Immunohistochemistry
Recommended Dilution:WB 1:2000-1:10000, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:OVCAR3
Cellular Location:Cell membrane, GPI-anchor, Golgi apparatus, Lipid-anchor, Secreted
Customer Validation:(mesothelioma, tonsil)

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 296-606 of human Mesothelin (NP_037536.2).
Sequence:EVEKT ACPSG KKARE IDESL IFYKK WELEA CVDAA LLATQ MDRVN AIPFT YEQLD VLKHK LDELY PQGYP ESVIQ HLGYL FLKMS PEDIR KWNVT SLETL KALLE VNKGH EMSPQ APRRP LPQVA TLIDR FVKGR GQLDK DTLDT LTAFY PGYLC SLSPE ELSSV PPSSI WAVRP QDLDT CDPRQ LDVLY PKARL AFQNM NGSEY FVKIQ SFLGG APTED LKALS QQNVS MDLAT FMKLR TDAVL PLTVA EVQKL LGPHV EGLKA EERHR PVRDW ILRQR QDDLD TLGLG LQGGI PNGYL VLDLS MQEAL S
Synonyms:MPF, SMRP
Calculated MW:69kDa
Observed MW:45kDa
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