MEF2D (Phospho-Ser444) Transcription Factor Activity Assay
- SKU:
- TFAB00055
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- MEF2D (Phospho-Ser444)
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
Description
| Product Name: | MEF2D (Phospho-Ser444) Transcription Factor Activity Assay |
| Product Code: | TFAB00055 |
| Target: | MEF2D (Phospho-Ser444) |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie MEF2D (Phospho-Ser444) transcription factor activity assay allows for the detection and qualitative analysis of MEF2D (Phospho-Ser444) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | MEF2D: transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in muscle-specific and/or growth factor-related transcription. Six splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 1q12-q23 Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription activator binding; transcription factor activity Biological Process: adult heart development; apoptosis; chondrocyte differentiation; endochondral ossification; muscle development; nervous system development; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] |
| UniProt Code: | Q14814 |
| NCBI GenInfo Identifier: | 2500876 |
| NCBI Gene ID: | 4209 |
| NCBI Accession: | Q14814.1 |
| UniProt Secondary Accession: | Q14814,Q14815, Q5T9U5, Q5T9U6, D3DVC0, |
| UniProt Related Accession: | Q14814 |
| Molecular Weight: | 49,856 Da |
| NCBI Full Name: | Myocyte-specific enhancer factor 2D |
| NCBI Synonym Full Names: | myocyte enhancer factor 2D |
| NCBI Official Symbol: | MEF2D |
| NCBI Protein Information: | myocyte-specific enhancer factor 2D |
| UniProt Protein Name: | Myocyte-specific enhancer factor 2D |
| Protein Family: | Myocyte-specific enhancer factor |
| UniProt Gene Name: | MEF2D |
| UniProt Entry Name: | MEF2D_HUMAN |
