Mcl1 Antibody (PACO28198)
- SKU:
- PACO28198
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Mcl1 Antibody (PACO28198) |
| Antibody SKU: | PACO28198 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog protein (1-308AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. |
| Synonyms: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1), Mcl1 |
| UniProt Protein Function: | MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.Protein type: Inhibitor; Channel, misc.; Mitochondrial; Apoptosis; Membrane protein, integralCellular Component: cytoplasm; cytosol; integral to membrane; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleusMolecular Function: BH domain binding; BH3 domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activityBiological Process: apoptosis; apoptotic mitochondrial changes; cell differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; negative regulation of apoptosis; regulation of apoptosis; response to cytokine stimulus |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P97287 |
| NCBI GenInfo Identifier: | 6678824 |
| NCBI Gene ID: | 17210 |
| NCBI Accession: | NP_032588.1 |
| UniProt Secondary Accession: | P97287,Q3TUS0, Q792P0, Q9CRI4, D2K6L9 |
| UniProt Related Accession: | P97287 |
| Molecular Weight: | 48.9 kDa |
| NCBI Full Name: | induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
| NCBI Synonym Full Names: | myeloid cell leukemia sequence 1 |
| NCBI Official Symbol: | Mcl1 |
| NCBI Official Synonym Symbols: | Mcl-1; AW556805 |
| NCBI Protein Information: | induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
| UniProt Protein Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
| UniProt Synonym Protein Names: | Bcl-2-related protein EAT/mcl1 |
| Protein Family: | Induced myeloid leukemia cell differentiation protein |
| UniProt Gene Name: | Mcl1 |
| UniProt Entry Name: | MCL1_MOUSE |
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