Description
Antibody Name: | MARCH2 Antibody |
Antibody SKU: | PACO04525 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the C-terminal region of human 40604. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MARCH2; RNF172; HSPC240; E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172 |
UniProt Protein Function: | MARCH2: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligaseChromosomal Location of Human Ortholog: 19p13.2Cellular Component: cytoplasmic vesicle; endoplasmic reticulumMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: protein ubiquitination |
UniProt Protein Details: | |
NCBI Summary: | MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010] |
UniProt Code: | Q9P0N8 |
NCBI GenInfo Identifier: | 53729332 |
NCBI Gene ID: | 51257 |
NCBI Accession: | NP_001005415.1 |
UniProt Secondary Accession: | Q9P0N8,Q5H785, Q8N5A3, Q96B78, A6NP10 |
UniProt Related Accession: | Q9P0N8 |
Molecular Weight: | |
NCBI Full Name: | E3 ubiquitin-protein ligase MARCH2 isoform 1 |
NCBI Synonym Full Names: | membrane associated ring-CH-type finger 2 |
NCBI Official Symbol: | MARCH2 |
NCBI Official Synonym Symbols: | RNF172; HSPC240; MARCH-II |
NCBI Protein Information: | E3 ubiquitin-protein ligase MARCH2 |
UniProt Protein Name: | E3 ubiquitin-protein ligase MARCH2 |
UniProt Synonym Protein Names: | Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172 |
Protein Family: | |
UniProt Gene Name: | MARCH2 |
UniProt Entry Name: | MARH2_HUMAN |