Description
Antibody Name: | MARCH1 Antibody |
Antibody SKU: | PACO04671 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the Internal region of human 40603. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MARCH1; RNF171; E3 ubiquitin-protein ligase MARCH1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; MARCH-I; RING finger protein 171 |
UniProt Protein Function: | MARCH1: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Membrane protein, multi-pass; EC 6.3.2.-; Membrane protein, integral; Ubiquitin ligaseChromosomal Location of Human Ortholog: 4q32.2Cellular Component: early endosome membrane; endoplasmic reticulum membrane; endosome; late endosome membrane; lysosomal membrane; lysosome; plasma membrane; trans-Golgi network membraneMolecular Function: MHC protein binding; ubiquitin-protein ligase activityBiological Process: antigen processing and presentation of peptide antigen via MHC class II; immune response; protein polyubiquitination |
UniProt Protein Details: | |
NCBI Summary: | MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010] |
UniProt Code: | Q8TCQ1 |
NCBI GenInfo Identifier: | 74762613 |
NCBI Gene ID: | 55016 |
NCBI Accession: | Q8TCQ1.1 |
UniProt Secondary Accession: | Q8TCQ1,Q9NWR0, D3DP29 |
UniProt Related Accession: | Q8TCQ1 |
Molecular Weight: | 30,873 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase MARCH1 |
NCBI Synonym Full Names: | membrane associated ring-CH-type finger 1 |
NCBI Official Symbol: | MARCH1 |
NCBI Official Synonym Symbols: | RNF171; MARCH-I |
NCBI Protein Information: | E3 ubiquitin-protein ligase MARCH1 |
UniProt Protein Name: | E3 ubiquitin-protein ligase MARCH1 |
UniProt Synonym Protein Names: | Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; MARCH-I; RING finger protein 171 |
Protein Family: | |
UniProt Gene Name: | MARCH1 |
UniProt Entry Name: | MARH1_HUMAN |