Antibody Name:	LZTFL1 Antibody (PACO16640)
Antibody SKU:	PACO16640
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human LZTFL1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Human transitional cell carcinoma tissue, 293T cells, A172 cells, human testis tissue, Hela cells, Primary antibody: PACO16640(LZTFL1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO16640(LZTFL1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.

Synonyms:

leucine zipper transcription factor-like 1

UniProt Protein Function:	LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17
UniProt Protein Details:
NCBI Summary:	This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
UniProt Code:	Q9NQ48
NCBI GenInfo Identifier:	74734310
NCBI Gene ID:	54585
NCBI Accession:	Q9NQ48.1
UniProt Secondary Accession:	Q9NQ48,Q8TC61, Q9NQ56, B3KSI9, B4E0K7
UniProt Related Accession:	Q9NQ48
Molecular Weight:	29,332 Da
NCBI Full Name:	Leucine zipper transcription factor-like protein 1
NCBI Synonym Full Names:	leucine zipper transcription factor like 1
NCBI Official Symbol:	LZTFL1
NCBI Official Synonym Symbols:	BBS17
NCBI Protein Information:	leucine zipper transcription factor-like protein 1
UniProt Protein Name:	Leucine zipper transcription factor-like protein 1
UniProt Synonym Protein Names:
Protein Family:	Leucine zipper transcription factor-like protein
UniProt Gene Name:	LZTFL1
UniProt Entry Name:	LZTL1_HUMAN