LRP5 Monoclonal Antibody (CAB21177)
- SKU:
- CAB21177
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | LRP5 Monoclonal Antibody |
| Product Code: | CAB21177 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52449 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HCT116, SW620, Mouse spleen, Mouse liver, Mouse lung |
| Cellular Location: | endoplasmic reticulum, plasma membrane |
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1400-1500 of human LRP5 (NP_002326.2). |
| Sequence: | MGGVY FVCQR VVCQR YAGAN GPFPH EYVSG TPHVP LNFIA PGGSQ HGPFT GIACG KSMMS SVSLM GGRGG VPLYD RNHVT GASSS SSSST KATLY PPILN P |
| Synonyms: | HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, LRP-5, LRP-7, OPTA1, PCLD4, VBCH2 |
| Calculated MW: | 179kDa |
| Observed MW: | 200kDa |
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