LPHN1 Antibody (PACO03669)
- SKU:
- PACO03669
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LPHN1 Antibody |
| Antibody SKU: | PACO03669 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human Latrophilin-1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | LPHN1; KIAA0821; LEC2; Latrophilin-1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2 |
| UniProt Protein Function: | Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (). |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] |
| UniProt Code: | O94910 |
| NCBI GenInfo Identifier: | 57165355 |
| NCBI Gene ID: | 22859 |
| NCBI Accession: | NP_001008701.1 |
| UniProt Secondary Accession: | O94910,Q96IE7, Q9BU07, Q9HAR3 |
| UniProt Related Accession: | O94910 |
| Molecular Weight: | 162,118 Da |
| NCBI Full Name: | adhesion G protein-coupled receptor L1 isoform 1 |
| NCBI Synonym Full Names: | adhesion G protein-coupled receptor L1 |
| NCBI Official Symbol: | ADGRL1 |
| NCBI Official Synonym Symbols: | CL1; LEC2; CIRL1; LPHN1 |
| NCBI Protein Information: | adhesion G protein-coupled receptor L1 |
| UniProt Protein Name: | Adhesion G protein-coupled receptor L1 |
| UniProt Synonym Protein Names: | Calcium-independent alpha-latrotoxin receptor 1 |
| Protein Family: | |
| UniProt Gene Name: | ADGRL1 |
| UniProt Entry Name: |
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