LIPI Antibody (PACO22389)
- SKU:
- PACO22389
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LIPI Antibody (PACO22389) |
| Antibody SKU: | PACO22389 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human LIPI. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO cells, using LIPI antibody. |
| Background: | Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). |
| Synonyms: | EC 3.1.1.-; lipase member I; LPD lipase; LPDL; membrane-associated phosphatidic acid-selective phospholipase A1-beta |
| UniProt Protein Function: | LIPI: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPI may be a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Secreted, signal peptide; Secreted; Phospholipase; EC 3.1.1.-Chromosomal Location of Human Ortholog: 21q11.2Cellular Component: plasma membraneMolecular Function: heparin binding; phospholipase activityBiological Process: lipid catabolic process; lipid digestionDisease: Hypertriglyceridemia, Familial |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q6XZB0 |
| NCBI GenInfo Identifier: | 81170675 |
| NCBI Gene ID: | 149998 |
| NCBI Accession: | Q6XZB0.2 |
| UniProt Secondary Accession: | Q6XZB0,G1JSG3, G1JSG4, G1JSG5, G1JSG6, G1JSG7, G1JSG8 G1JSG9 |
| UniProt Related Accession: | Q6XZB0 |
| Molecular Weight: | 34,110 Da |
| NCBI Full Name: | Lipase member I |
| NCBI Synonym Full Names: | lipase I |
| NCBI Official Symbol: | LIPI |
| NCBI Official Synonym Symbols: | CT17; LPDL; PLA1C; PRED5; mPA-PLA1 beta |
| NCBI Protein Information: | lipase member I |
| UniProt Protein Name: | Lipase member I |
| UniProt Synonym Protein Names: | Cancer/testis antigen 17; CT17; LPD lipase; Membrane-associated phosphatidic acid-selective phospholipase A1-beta; mPA-PLA1 beta |
| Protein Family: | Lipase |
| UniProt Gene Name: | LIPI |
| UniProt Entry Name: | LIPI_HUMAN |
| Antibodies |
| LIPI Antibody (PACO01028) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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