LIN28A Monoclonal Antibody
- SKU:
- CAB21261
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | LIN28A Monoclonal Antibody |
| Product Code: | CAB21261 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53062 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:10000-1:70000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | T-47D, NCCIT |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus |
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-209 of human LIN28A (NP_078950.1). |
| Sequence: | SAKGL ESIRV TGPGG VFCIG SERRP KGKSM QKRRS KGDRC YNCGG LDHHA KECKL PPQPK KCHFC QSISH MVASC PLKAQ QGPSA QGKPT YFREE EEEIH SPTLL PEAQN |
| Synonyms: | CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A |
| Calculated MW: | 23kDa |
| Observed MW: | 28kDa |
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