LCK Monoclonal Antibody
- SKU:
- CAB23988
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | LCK Monoclonal Antibody |
| Product Code: | CAB23988 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC61836 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:2000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Molt-4, Mouse thymus, Mouse spleen |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor |
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human LCK (NP_005347.3). |
| Sequence: | MGCGC SSHPE DDWME NIDVC ENCHY PIVPL DGKGT LLIRN GSEVR DPLVT YEGSN PPASP LQDNL VIALH SYEPS HDGDL GFEKG EQLRI LEQSG EWWKA QSLTT GQEGF IPFNF VAKAN SLEPE PWFFK NLSRK DAERQ LLAPG NTHGS FLIRE SESTA GSFSL SVRDF DQNQG EVVKH YKIRN LDNGG FYISP RITFP GLHEL VRHYT |
| Synonyms: | LSK, YT16, IMD22, p56lck, pp58lck |
| Calculated MW: | 58kDa |
| Observed MW: | 58kDa |
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