KPNA6 Monoclonal Antibody (CAB24825)

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SKU:
CAB24825
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF

Description

Product Name:KPNA6 Monoclonal Antibody
Product Code:CAB24825
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC64379
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:2000-1:20000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa
Cellular Location:cytosol, nucleoplasm, nucleus

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 69-169 of human KPNA6 (NP_036448.1).
Sequence:DSYVS STTGE SVITR EMVEM LFSDD SDLQL ATTQK FRKLL SKEPS PPIDE VINTP RVVDR FVEFL KRNEN CTLQF EAAWA LTNIA SGTSQ QTKIV IEAGA V
Synonyms:IPOA7
Calculated MW:60kDa
Observed MW:60kDa
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