Description
Antibody Name: | KDELR2 Antibody |
Antibody SKU: | PACO00996 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human KDEL Receptor 2. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | KDELR2; ERD2.2; ER lumen protein retaining receptor 2; ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2 |
UniProt Protein Function: | KDELR2: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. Belongs to the ERD2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 7p22.1Cellular Component: cis-Golgi network; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to membraneMolecular Function: KDEL sequence bindingBiological Process: intracellular protein transport; protein retention in ER; vesicle-mediated transport |
UniProt Protein Details: | |
NCBI Summary: | Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | P33947 |
NCBI GenInfo Identifier: | 462018 |
NCBI Gene ID: | 11014 |
NCBI Accession: | P33947.1 |
UniProt Secondary Accession: | P33947,Q6IPC5, Q96E30, A4D2P4 |
UniProt Related Accession: | P33947 |
Molecular Weight: | 21,242 Da |
NCBI Full Name: | ER lumen protein-retaining receptor 2 |
NCBI Synonym Full Names: | KDEL endoplasmic reticulum protein retention receptor 2 |
NCBI Official Symbol: | KDELR2 |
NCBI Official Synonym Symbols: | ELP-1; ERD2.2 |
NCBI Protein Information: | ER lumen protein-retaining receptor 2 |
UniProt Protein Name: | ER lumen protein-retaining receptor 2 |
UniProt Synonym Protein Names: | ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2 |
Protein Family: | ER lumen protein-retaining receptor |
UniProt Gene Name: | KDELR2 |
UniProt Entry Name: | ERD22_HUMAN |