[KD Validated] PROM1 Polyclonal Antibody

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SKU:
CAB21701
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC
Applications:
IP
Applications:
IF

Description

Product Name:[KD Validated] PROM1 Polyclonal Antibody
Product Code:CAB21701
Reactivity:Human, Rat
Applications:Western blotting, Immunohistochemistry, Immunoprecipitation, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Rat
Tested Applications:WB, IHC-P, IF/ICC, IP, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunoprecipitation, Immunofluorescence
Recommended Dilution:WB 1:100-1:500, IHC-P 1:50-1:200, IP 1:500-1:1000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HT-29, HCT116
Cellular Location:Apical cell membrane, Cell projection, Endoplasmic reticulum, Endoplasmic reticulum-Golgi intermediate compartment, Multi-pass membrane protein, cilium, microvillus membrane, photoreceptor outer segment

This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 179-433 of human PROM1 (NP_006008.1).
Sequence:ANHQV RTRIK RSRKL ADSNF KDLRT LLNET PEQIK YILAQ YNTTK DKAFT DLNSI NSVLG GGILD RLRPN IIPVL DEIKS MATAI KETKE ALENM NSTLK SLHQQ STQLS SSLTS VKTSL RSSLN DPLCL VHPSS ETCNS IRLSL SQLNS NPELR QLPPV DAELD NVNNV LRTDL DGLVQ QGYQS LNDIP DRVQR QTTTV VAGIK RVLNS IGSDI DNVTQ RLPIQ DILSA FSVYV NNTES YIHRN LPTLE EYDSY
Synonyms:RP41, AC133, CD133, MCDR2, STGD4, CORD12, PROML1, MSTP061
Calculated MW:97kDa
Observed MW:120kDa
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