[KD Validated] NPHS1 Polyclonal Antibody

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SKU:
CAB21985
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:[KD Validated] NPHS1 Polyclonal Antibody
Product Code:CAB21985
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:A-549
Cellular Location:Cell membrane, Single-pass type I membrane protein

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1019-1241 of human NPHS1 (NP_004637.1).
Sequence:LGDSG LADKG TQLPI TTPGL HQPSG EPEDQ LPTEP PSGPS GLPLL PVLFA LGGLL LLSNA SCVGG VLWQR RLRRL AEGIS EKTEA GSEED RVRNE YEESQ WTGER DTQSS TVSTT EAEPY YRSLR DFSPQ LPPTQ EEVSY SRGFT GEDED MAFPG HLYDE VERTY PPSGA WGPLY DEVQM GPWDL HWPED TYQDP RGIYD QVAGD LDTLE PDSLP FELRG HLV
Synonyms:CNF, NPHN, nephrin
Calculated MW:135kDa
Observed MW:200kDa
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