[KD Validated] Gelsolin Polyclonal Antibody

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SKU:
CAB22015
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC

Description

Product Name:[KD Validated] Gelsolin Polyclonal Antibody
Product Code:CAB22015
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, ELISA
Key Applications:Western blotting, Immunohistochemistry
Recommended Dilution:WB 1:100-1:500, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa, HepG2, C2C12
Cellular Location:actin cytoskeleton, blood microparticle, cortical actin cytoskeleton, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, focal adhesion, phagocytic vesicle, plasma membrane, podosome

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 28-782 of human Gelsolin (NP_000168.1).
Sequence:ATASR GASQA GAPQG RVPEA RPNSM VVEHP EFLKA GKEPG LQIWR VEKFD LVPVP TNLYG DFFTG DAYVI LKTVQ LRNGN LQYDL HYWLG NECSQ DESGA AAIFT VQLDD YLNGR AVQHR EVQGF ESATF LGYFK SGLKY KKGGV ASGFK HVVPN EVVVQ RLFQV KGRRV VRATE VPVSW ESFNN GDCFI LDLGN NIHQW CGSNS NRYER LKATQ VSKGI RDNER SGRAR VHVSE EGTEP EAMLQ VLGPK PALPA GTEDT AKEDA ANRKL AKLYK VSNGA GTMSV SLVAD ENPFA QGALK SEDCF ILDHG KDGKI FVWKG KQANT EERKA ALKTA SDFIT KMDYP KQTQV SVLPE GGETP LFKQF FKNWR DPDQT DGLGL SYLSS HIANV ERVPF DAATL HTSTA MAAQH GMDDD GTGQK QIWRI EGSNK VPVDP ATYGQ FYGGD SYIIL YNYRH GGRQG QIIYN WQGAQ STQDE VAASA ILTAQ LDEEL GGTPV QSRVV QGKEP AHLMS LFGGK PMIIY KGGTS REGGQ TAPAS TRLFQ VRANS AGATR AVEVL PKAGA LNSND AFVLK TPSAA YLWVG TGASE AEKTG AQELL RVLRA QPVQV AEGSE PDGFW EALGG KAAYR TSPRL KDKKM DAHPP RLFAC SNKIG RFVIE EVPGE LMQED LATDD VMLLD TWDQV FVWVG KDSQE EEKTE ALTSA KRYIE TDPAN RDRRT PITVV KQGFE PPSFV GWFLG WDDDY WSVDP LDRAM AELAA
Synonyms:ADF, AGEL
Calculated MW:86kDa
Observed MW:86kDa
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