![ISG15 Monoclonal Antibody [P3E5AT] (CPAB0518)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58739/63921/isg15-monoclonal-antibody-p3e5at-cpab0518__39073__21135.1706535201.jpg?c=1?imbypass=on "ISG15 Monoclonal Antibody [P3E5AT] (CPAB0518)")
Description
system_update_alt Datasheet
| Product Name: | ISG15 Antibody |
| Product Sku: | CPAB0518 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human ISG15 mAb is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ISG15 amino acids 1-157 purified from Ecoli. |
| Clone: | P3E5AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA |
| Purification Method: | ISG15 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG1 |
| Background: | ISG15 ubiquitin-like Modifier is conjugated to the intracellular target proteins after IFN-alpha or IFN-beta stimulation. ISG15 enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the ub conjugation pathway at the level of a specific E2 enzyme. ISG15 protein targets include STAT1, SERPINA 3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MXA, and RIG-1. Deconjugated by USP18/UBP43 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. ISG15 serves as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. ISG15 plays a role in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing ifn-gamma secretion by monocytes and macrophages. ISG15 displays a |
| Synonyms: | ISG15, G1P2, IFI15, UCRP, Interferon-induced 17 kDa protein precursor, ISG15 Ubiquitin-like modifier. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
![ISG15 Monoclonal Antibody [P3E5AT] (CPAB0518)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58739/63921/isg15-monoclonal-antibody-p3e5at-cpab0518__39073__21135.1706535201.jpg?c=1 "ISG15 Monoclonal Antibody [P3E5AT] (CPAB0518)")
![VAMP2 Monoclonal Antibody [P3E5AT] (CPAB0519)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58740/63922/vamp2-monoclonal-antibody-p3e5at-cpab0519__16096__99064.1706535201.jpg?c=1 "VAMP2 Monoclonal Antibody [P3E5AT] (CPAB0519)")
![[KD Validated] ISG15 Polyclonal Antibody](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/82262/87051/A21995_1__39342__73867.1706547172.jpg?c=1 "[KD Validated] ISG15 Polyclonal Antibody")
