ISG15 Monoclonal Antibody [P3E5AT] (CPAB0518)

Name: ISG15 Monoclonal Antibody [P3E5AT] (CPAB0518)
SKU: CPAB0518
Availability: OutOfStock

(No reviews yet) Write a Review

Description

View AllClose

View AllClose

system_update_alt Datasheet Overview

Immunology Antibodies 1

Immunology Antibodies 3

OverviewProduct Name:[KD Validated] ISG15 Polyclonal AntibodyProduct Code:CAB21995Reactivity:HumanApplications:Western blotting</

Bovine Immunology ELISA Kits

Product Name:	ISG15 Antibody
Product Sku:	CPAB0518
Size:	5μg
Host Species:	Mouse
Immunogen:	Anti-human ISG15 mAb is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ISG15 amino acids 1-157 purified from Ecoli.
Clone:	P3E5AT.
Reactivity:	Other bodies
Applications:	Western Blot, ELISA

Purification Method:	ISG15 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:	IgG1
Background:	ISG15 ubiquitin-like Modifier is conjugated to the intracellular target proteins after IFN-alpha or IFN-beta stimulation. ISG15 enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the ub conjugation pathway at the level of a specific E2 enzyme. ISG15 protein targets include STAT1, SERPINA 3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MXA, and RIG-1. Deconjugated by USP18/UBP43 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. ISG15 serves as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. ISG15 plays a role in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing ifn-gamma secretion by monocytes and macrophages. ISG15 displays a
Synonyms:	ISG15, G1P2, IFI15, UCRP, Interferon-induced 17 kDa protein precursor, ISG15 Ubiquitin-like modifier.
Storage Buffer:	For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.