IRF1 Polyclonal Antibody
- SKU:
- CAB21467
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | IRF1 Polyclonal Antibody |
| Product Code: | CAB21467 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat |
| Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 221-310 of human IRF1 (NP_002189.1). |
| Sequence: | SEATT DEDEE GKLPE DIMKL LEQSE WQPTN VDGKG YLLNE PGVQP TSVYG DFSCK EEPEI DSPGG DIGLS LQRVF TDLKN MDATW LDSLL |
| Synonyms: | MAR, IRF-1 |
| Calculated MW: | 37kDa |
| Observed MW: | 48kDa |
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