IκBα Polyclonal Antibody (CAB21510)
- SKU:
- CAB21510
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | IκBα Polyclonal Antibody |
| Product Code: | CAB21510 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Nucleus |
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IκBα (NP_065390.1). |
| Sequence: | MFQAA ERPQE WAMEG PRDGL KKERL LDDRH DSGLD SMKDE EYEQM VKELQ EIRLE PQEVP RGSEP WKQQL TEDGD SFLHL AIIHE EKALT MEVIR QVKGD LAFLN FQNNL QQTPL HLAVI TNQPE IAEAL LGAGC DPELR DFRGN TPLHL ACEQG CLASV GVLTQ SCTTP HLHSI LKATN YNGHT CLHLA SIHGY LGIVE LLVSL GADVN AQEPC NGRTA LHLAV DLQNP DLVSL LLKCG ADVNR VTYQG YSPYQ LTWGR PSTRI QQQLG QLTLE NLQML PESED EESYD TESEF TEFTE DELPY DDCVF GGQRL TL |
| Synonyms: | IKBA, MAD-3, NFKBI, EDAID2 |
| Calculated MW: | 36kDa |
| Observed MW: | Refer to figures |
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