IκBα Monoclonal Antibody

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SKU:
CAB24909
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF

Description

Product Name:IκBα Monoclonal Antibody
Product Code:CAB24909
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC63567
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:2000-1:7000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:Mouse thymus, Mouse liver (Low expression control)
Cellular Location:Cytoplasm, Nucleus

Enables NF-kappaB binding activity and heat shock protein binding activity. Involved in several processes, including cytoplasmic sequestering of NF-kappaB; leukocyte migration involved in inflammatory response; and liver regeneration. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol and nucleus. Part of protein-containing complex. Used to study gastritis; pulmonary emphysema; and sciatic neuropathy. Biomarker of several diseases, including acute necrotizing pancreatitis; alcoholic hepatitis; artery disease (multiple); middle cerebral artery infarction; and toxic shock syndrome. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; hematologic cancer (multiple); hepatitis B; hepatitis C; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha).

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of Rat IκBα(NP_001099190.2).
Sequence:MFQPA GHGQD WAMEG PRDGL KKERL VDDRH DSGLD SMKDE DYEQM VKELR EIRLQ PQEAP LAAEP WKQQL TEDGD SFLHL AIIHE EKTLT MEVIG QVKGD LAFLN FQNNL QQTPL HLAVI TNQPG IAEAL LKAGC DPELR DFRGN TPLHL ACEQG CLASV AVLTQ TCTPQ HLHSV LQATN YNGHT CLHLA SIHGY LGIVE HLVTL GADVN AQEPC NGRTA LHLAV DLQNP DLVSL LLKCG ADVNR VTYQG YSPYQ LTWGR PSTRI QQQLG QLTLE NLQTL PESED EESYD TESEF TEDEL PYDDC VFGGQ RLTL
Synonyms:RL/IF-1
Calculated MW:35kDa
Observed MW:40kDa
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