Human ZP3 / Zona pellucida sperm-binding protein 3 ELISA Kit

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SKU:
HUFI01095
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P21754
Sensitivity:
0.375ng/ml
Range:
0.625-40ng/ml
ELISA Type:
Sandwich
Synonyms:
ZP3, Zona pellucida sperm-binding protein 3, ZP3A, ZP3B, ZPC, Zp-3, Zona pellucida protein C, Zona pellucida glycoprotein 3, Sperm receptor, ZP3A, ZP3B,
Reactivity:
Human
Research Area:
Developmental Biology

Description

Human ZP3 / Zona pellucida sperm-binding protein 3 ELISA Kit

The oocyte and early embryo are surrounded by an extracellular matrix called the zona pellucida. It's mostly made up of three or four glycoproteins that play different roles during fertilisation and preimplantation development. ZP3 is a structural component of the zona pellucida and is involved in sperm acrosome reaction primary binding and induction. The nascent protein has a signal peptide sequence at the N-terminus, a conserved ZP domain at the C-terminus, a consensus furin cleavage site at the C-terminus, and a transmembrane domain at the C-terminus. Furin cleavage is thought to result in the release of the mature protein from the plasma membrane, which is then incorporated into the zona pellucida matrix. However, based on mouse studies, the requirement for furin cleavage in this process is still debatable. Oocyte Maturation Defect 3 and Female Infertility Due To Zona Pellucida Defect are two diseases linked to ZP3.

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