Human ZNRD1 Recombinant Protein (RPPB5182)
- SKU:
- RPPB5182
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9P1U0
Description
| Product Name: | Human ZNRD1 Recombinant Protein |
| Product Code: | RPPB5182 |
| Size: | 20µg |
| Species: | Human |
| Target: | ZNRD1 |
| Synonyms: | Zinc Ribbon Domain Containing 1, Zinc Ribbon DomainContaining, 1, HTEX-6, Rpa12, TEX6, ZR14, DNA-Directed RNA Polymerase I SubunitRPA12, hZR14, RNA Polymerase I Small Specific Subunit Rpa12, tctex-6, Transcription-AssociatedZinc Ribbon Protein, RPA12, Zinc Ribbon Domain-Containing Protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | ZNRD1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSVMDLA NTCSSFQSDL DFCSDCGSVL PLPGAQDTVT CIRCGFNINV RDFEGKVVKT SVVFHQLGTA MPMSVEEGPE CQGPVVDRRC PRCGHEGMAY HTRQMRSADE GQTVFYTCTN CKFQEKEDS |
ZincRibbon Domain Containing 1 (ZNRD1) is a protein which shows similarity to theSaccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. ZNRD1 contains two potentialzinc-binding motifs and takes part in regulation of cell proliferation. ZNRD1is involved in cancer and human immunodeficiency virus progression. Alternatesplicing of this gene results in two transcript variants encoding the sameprotein. Additional splice variants have been found, but their full-lengthsequences have not been determined.
ZNRD1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 149 amino acids (1-126a.a) andhaving a molecular mass of 16.3kDa.ZNRD1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ZNRD1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. |
| UniProt Protein Details: | Protein type:Transcription initiation complex; Transferase; Nucleolus Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: DNA-directed RNA polymerase I complex; nucleoplasm Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter |
| NCBI Summary: | This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9P1U0 |
| NCBI GenInfo Identifier: | 71649339 |
| NCBI Gene ID: | 30834 |
| NCBI Accession: | Q9P1U0.1 |
| UniProt Secondary Accession: | Q9P1U0,Q1RMP0, Q5TM50, Q791N7, Q1XHV8, Q6MFY5, |
| UniProt Related Accession: | Q9P1U0 |
| Molecular Weight: | 13,904 Da |
| NCBI Full Name: | DNA-directed RNA polymerase I subunit RPA12 |
| NCBI Synonym Full Names: | zinc ribbon domain containing 1 |
| NCBI Official Symbol: | ZNRD1�� |
| NCBI Official Synonym Symbols: | TEX6; ZR14; HTEX6; Rpa12; hZR14; HTEX-6; TCTEX6; tctex-6�� |
| NCBI Protein Information: | DNA-directed RNA polymerase I subunit RPA12 |
| UniProt Protein Name: | DNA-directed RNA polymerase I subunit RPA12 |
| UniProt Synonym Protein Names: | Zinc ribbon domain-containing protein 1 |
| UniProt Gene Name: | ZNRD1�� |
| UniProt Entry Name: | RPA12_HUMAN |
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