Human ZCCHC12 Recombinant Protein (RPPB5176)

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SKU:
RPPB5176
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q6PEW1

Description

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Product Name:Human ZCCHC12 Recombinant Protein
Product Code:RPPB5176
Size:20µg
Species:Human
Target:ZCCHC12
Synonyms:PNMA7A, SIZN, SIZN1, Zinc finger CCHC domain-containing protein 12, Smad-interacting zinc finger protein 1, ZCCHC12.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ZCCHC12 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMASIIAR VGNSRRLNAP LPPWAHSMLR SLGRSLGPIM ASMADRNMKL FSGRVVPAQG EETFENWLTQ VNGVLPDWNM SEEEKLKRLM KTLRGPAREV MRVLQATNPN LSVADFLRAM KLVFGESESS VTAHGKFFNT LQAQGEKASL YVIRLEVQLQ NAIQAGIIAE KDANRTRLQQ LLLGGELSRD LRLRLKDFLR MYANEQERLP NFLELIRMVR EEEDWDDAFI KRKRPKRSES MVERAVSPVA FQGSPPIVIG SADCNVIEID DTLDDSDEDV ILVESQDPPL PSWGAPPLRD RARPQDEVLV IDSPHNSRAQ FPSTSGGSGY KNNGPGEMRR ARKRKHTIRC SYCGEEGHSK ETCDNESDKA QVFENLIITL QELTHTEMER SRVAPGEYND FSEPL

Zinc Finger, CCHC Domain Containing 12 (ZCCHC12) which holds 1 CCHC-type zinc finger is a part of the ZCCHC12 family. ZCCHC12 takes part in the bone morphogenetic protein (BMP)-signaling pathway as a transcriptional coactivator. BMP signaling is positively modulated as a result of the interaction between ZCCHC12 with SMAD1 and the association with CBP in the transcription complex.

ZCCHC12 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 425 amino acids (1-402 a.a) and having a molecular mass of 47.8kDa. ZCCHC12 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ZCCHC12: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Belongs to the ZCCHC12 family.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: nuclear speck

Molecular Function:ligand-dependent nuclear receptor transcription coactivator activity; protein binding

Biological Process: BMP signaling pathway

NCBI Summary:This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
UniProt Code:Q6PEW1
NCBI GenInfo Identifier:85718626
NCBI Gene ID:170261
NCBI Accession:Q6PEW1.2
UniProt Secondary Accession:Q6PEW1,Q6PID5, Q8N1C1, B3KV48,
UniProt Related Accession:Q6PEW1
Molecular Weight:45,369 Da
NCBI Full Name:Zinc finger CCHC domain-containing protein 12
NCBI Synonym Full Names:zinc finger CCHC-type containing 12
NCBI Official Symbol:ZCCHC12��
NCBI Official Synonym Symbols:SIZN; SIZN1; PNMA7A��
NCBI Protein Information:zinc finger CCHC domain-containing protein 12
UniProt Protein Name:Zinc finger CCHC domain-containing protein 12
UniProt Synonym Protein Names:Smad-interacting zinc finger protein 1
Protein Family:Zinc finger CCHC domain-containing protein
UniProt Gene Name:ZCCHC12��
UniProt Entry Name:ZCH12_HUMAN
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