Human YBX1 Recombinant Protein (RPPB5170)
- SKU:
- RPPB5170
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P67809
Description
| Product Name: | Human YBX1 Recombinant Protein |
| Product Code: | RPPB5170 |
| Size: | 20µg |
| Species: | Human |
| Target: | YBX1 |
| Synonyms: | Y Box Binding Protein, NSEP1,DBPB, YB1, CCAAT-Binding Transcription Factor I Subunit A, Nuclease Sensitive Element Binding Protein, Enhancer Factor I Subunit A, Y-Box Transcription Factor, Y-Box-Binding Protein, DNA-Binding P, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, EFI-A, YB-1, Major Histocompatibility Complex Class II Y Box-Binding Protein I. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | YBX1 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH7.4) and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSSEAET QQPPAAPPAA PALSAADTKP GTTGSGAGSG GPGGLTSAAP AGGDKKVIAT KVLGTVKWFN VRNGYGFINR NDTKEDVFVH QTAIKKNNPR KYLRSVGDGE TVEFDVVEGE KGAEAANVTG PGGVPVQGSK YAADRNHYRR YPRRRGPPRN YQQNYQNSES GEKNEGSESA PEGQAQQRRP YRRRRFPPYY MRRPYGRRPQ YSNPPVQGEV MEGADNQGAG EQGRPVRQNM YRGYRPRFRR GPPRQRQPRE DGNEEDKENQ GDETQGQQPP QRRYRRNFNY RRRRPENPKP QDGKETKAAD PPAENSSAPE AEQGGAE |
Y Box Binding Protein 1 (YBX1) is a part of the CRD-mediated complex which promotes MYC mRNA stability. YBX1 takes part in mammalian selenoprotein translation and mediates pre-mRNA alternative splicing regulation. YBX1 uses as a drug target in cancer therapy due to its ability to replicate adenovirus type 5, a commonly used vector in gene therapy.
YBX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 347 amino acids (1-324a.a) and having a molecular mass of 38.3kDa (molecular size on SDS-PAGE will appear higher). YBX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | YB-1: a nuclear protein that binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors CCAAT-containing Y-box of HLA class II genes. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, SFRS9, THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP. Involved in cisplatin resistance. Seems to be a negative regulatory factor. May play a role in both transcriptional and translational regulation of spermatogenesis. Found at very low levels at day 10 and levels increase at day 15 and persist throughout adulthood. |
| UniProt Protein Details: | Protein type:Transcription factor; RNA-binding; RNA splicing; RNA processing Chromosomal Location of Human Ortholog: 1p34 Cellular Component: nucleoplasm; nuclear membrane; intracellular membrane-bound organelle; stress granule; cytoplasm; nucleus; ribonucleoprotein complex; U12-dependent spliceosome Molecular Function:protein binding; DNA binding; RNA binding; double-stranded DNA binding; transcription factor activity; single-stranded DNA binding Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; negative regulation of striated muscle cell differentiation; regulation of transcription, DNA-dependent; in utero embryonic development; positive regulation of cell division; RNA splicing; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | P67809 |
| NCBI GenInfo Identifier: | 34098946 |
| NCBI Gene ID: | 4904 |
| NCBI Accession: | NP_004550.2 |
| UniProt Secondary Accession: | P67809,P16990, P16991, Q14972, Q15325, Q5FVF0, |
| UniProt Related Accession: | P67809 |
| Molecular Weight: | 35,924 Da |
| NCBI Full Name: | nuclease-sensitive element-binding protein 1 |
| NCBI Synonym Full Names: | Y box binding protein 1 |
| NCBI Official Symbol: | YBX1�� |
| NCBI Official Synonym Symbols: | YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1�� |
| NCBI Protein Information: | nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit |
| UniProt Protein Name: | Nuclease-sensitive element-binding protein 1 |
| UniProt Synonym Protein Names: | CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1 |
| Protein Family: | Nuclease-sensitive element-binding protein |
| UniProt Gene Name: | YBX1�� |
| UniProt Entry Name: | YBOX1_HUMAN |
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